Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug.In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss.Also the authors noted that the long-term effects have not been studied.Dispensing errors have been reported between Topamax (topiramate) tablets and Toprol-XL (metoprolol succinate) extended-release tablets thereby requiring extra care to ensure the correct medication is being taken. People taking topiramate should be aware of the following risks: The U. Food and Drug Administration (FDA) has notified prescribers that topiramate can cause acute myopia and secondary angle closure glaucoma in a small subset of people who take topiramate regularly.Unless safety concerns require an abrupt withdrawal of the concomitant AED, a gradual discontinuation at the rate of approximately one-third of the concomitant AED dose every 2 weeks is recommended.Dose and titration should be guided by clinical response.
Addition or withdrawal of phenytoin and carbamazepine to adjunctive therapy with Topamax may require adjustment of the dose of Topamax.
Average total daily dose: Taken alone: 100mg daily (up to 18 years) or 100 – 200mg daily (over 18 years).
Taken with other AEDs: 5 – 9mg/kg daily (up to 18 years) or 200 – 400mg daily (over 18 years). Doses per day: 2 Treatment: Used for focal seizures with or without secondary generalisation and tonic clonic seizures, where other treatment has not worked.
First of all, physicians and psychiatrists sometimes prescribe it when other mood-stabilizing drugs fail to be effective for a patient.
Secondly, the set of side effects that patients may experience is quite different on Topiramate compared to other mood stabilizers.